Oligonucleotide conjugates open up opportunities to deliver the oligonucleotide to a specific cell or tissue and to fine-tune the ‘drug-like’ properties. However, the complexity of conjugation chemistry poses great challenges for drug innovators and manufacturers.
WuXi TIDES is well positioned to provide a one-stop solution for complex oligonucleotide-conjugate drugs from discovery to development and commercial manufacturing, with our strong capabilities in both oligonucleotide, peptide and small molecules including ligand, toxin, linker, lipid, PEG etc.
Why choose WuXi TIDES?
Comprehensive: Extensive experience in various modalities
Diversity : Large variety of linkers / conjugation strategies
Flexibility : Custom-tailored solution according to your application
Type of oligo conjugates:
|Amide Coupling||Broad selection of spacers|
|Thiol-maleimide addition||Custom-tailored linkers|
|Click chemistry (CuAAC | SPAAC)|
|3'- or 5'-conjugation||Complex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)|
|Internal conjugation||Multi-valency (Mono- / di- / tri- / tetra)|