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Oligonucleotide Conjugate

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Oligonucleotide Conjugate

Oligonucleotide Discovery

Oligonucleotide CMC

Oligonucleotide Conjugate

Oligo Monomer & Ligand

Oligonucleotide conjugates open up opportunities to deliver the oligonucleotide to a specific cell or tissue and to fine-tune the ‘drug-like’ properties. However, the complexity of conjugation chemistry poses great challenges for drug innovators and manufacturers.

WuXi TIDES is well positioned to provide a one-stop solution for complex oligonucleotide-conjugate drugs from discovery to development and commercial manufacturing, with our strong capabilities in both oligonucleotide, peptide and small molecules including ligand, toxin, linker, lipid, PEG etc.


Why choose WuXi TIDES?

  • Comprehensive: Extensive experience in various modalities

  • Diversity : Large variety of linkers / conjugation strategies

  • Flexibility :  Custom-tailored solution according to your application


Type of oligo conjugates: 

PPMOPeptide-Oligo (POC)
GalNAc-Oligo'Drug'-Oligo
Lipid-OligoDye-labelled Oligo


Linker Chemistry: 

Amide CouplingBroad selection of spacers
Thiol-maleimide additionCustom-tailored linkers
Click chemistry (CuAAC | SPAAC)


Topology

3'- or 5'-conjugationComplex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)
Internal conjugationMulti-valency (Mono- / di- / tri- / tetra)
Base/backbone conjugation
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Lipid

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Peptide

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Carbohydrate

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Fluorescent-dye

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PEG