Oligonucleotide Synthesis
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Oligonucleotide Discovery
Oligonucleotide Discovery
Oligonucleotide CMC
Oligonucleotide Conjugate
Oligo Monomer & Ligand
Oligonucleotide Synthesis
Oligonucleotide Synthesis
Our oligo drug discovery platform has a few hundreds of dedicated scientists and state-of-the-art facilities, providing oligonucleotide library synthesis (nmol - µmol) and custom synthesis (µmol – mmol) covering all oligo types including DNA, ASO, siRNA, microRNA, saRNA, sgRNA, circRNA, hairpin oligos, CpG ODN, Aptamer, PMO, degenerate oligonucleotides etc., with or without conjugation, coupled with dedicated analytical support for all required testing.
Oligonucleotide high throughput library synthesis (nmol - µmol)
192 channel synthesizers with up to 1 µmol set up for each column
High purity by high throughput RP-HPLC or OPC™ (Oligonucleotide Purification Cartridge) purification
Fast delivery: about 10 days to complete ~200 ds RNA
Selected past projects:
234 siRNA duplex library synthesis within 2 weeks (200 nmol each)
144 5'-SMCC DNA Aptamers library synthesis within 2 weeks (375 nmol each)
206 PMO library synthesis within 2 months (300 nmol each)
Oligonucleotide custom synthesis (µmol - mmol)
Synthesizers up to 16 monomers selection enables highly modified oligo synthesis, ÄKTA OligoPilotTM 10, ÄKTA OligoPilotTM 100
Expertise in long oligo synthesis for both ss RNA and ds RNA
Experience with diverse challenging modified oligo synthesis such as ASO with all chiral phosphorothioates, RNA with 3'/5'-GalNAc, lipidation, PEGylation, etc.
Large capacity: deliver 2,000+ oligo molecules per month, endotoxin level control (<1EU/mg)