Our oligonucleotide API process development and manufacturing platform provides one-stop solution from preclinical to commercial from one site in Changzhou, China. We have built industry-leading capability and capacity to support your needs across all development stages, with knowledge retention through the product life cycle. In addition, Changzhou site is within 1-hour drive from drug product site in Wuxi city, enabling faster, simpler and more cost effective oligo CMC development for both API and drug product.
A highly experienced oligo R&D team with a few hundreds of scientists with 100+ projects completed
Cover molecule types of ASO, siRNA, Aptamer, Oligo conjugates, PMO and PPMO
Utilize various modified monomers (2'-H, 2'-OH, 2'-F, 2'-OMe, 2'-OMOE, LNA, cEt, LNA, Vinyl-phosphate, Spacer,…)
Chiral oligo synthesis
Modification at 3'-end or 5'-end with GalNAc, triphosphate, cholesterol, saccharides, peptides, maleimide…
With our global standard quality system, we are uniquely positioned to be your strategic manufacturing partner for reliable, cost effective and long-term supplies of your oligonucleotide APIs from mmol to mol. Our unique "one-site" platform ensures knowledge retention and seamless scale up throughout your product life cycle, and expediates your development by eliminating the trouble of multi companies/sites transfer.
Capacity Expansion Plan
Currently we have 4 large-scale lines with 6 mol total capacity per synthesis run. By 2024, we will have 7 large-scale lines.
UF / DF / TFE
Thin Film Evaporator
0.5 m2 - 20 m2
Access to new technologies
The traditional oligo development and manufacturing process faces many sustainability challenges, such as high waste, poor atom economy and low energy efficiency.
WuXi TIDES provides our global customers open access to novel technologies for oligonucleotide development and manufacturing, including the following technologies, toward a greener, more efficient and cost effective process.