N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose. GalNAc conjugation represents an efficient way of increasing siRNA target organ accumulation and of facilitating their cellular uptake.
Our team has rich experience in all popular GalNAc molecules, including synthesis and analytical method development. We provide GalNAc custom synthesis, process development and GMP manufacturing.
With our oligo team on the same site, we provide a streamlined GalNAc-oligo development and manufacturing service.
WuXi STA Advantage
There are many synthetic challenges for GalNAc because most of the intermediates are oily or foamy solids. The synthesis involves many column and prep-HPLC purification steps, resulting scale-up difficulties and low yields. Analytical method for GalNAc synthesis is also challenging due to low UV response, complex impurity profile and poor stability.
WuXi STA developed convergent routes with telescoping processes without column purification steps. The isolated intermediates are stable solids. We apply the precipitation process and/or spray drying process to reduce the need for column and prep-HPLC steps. Our analytical team identify many GalNAc related impurities to support method development and release testing.